It is not uncommon for the BHMT and CBS variants to cause an increase in glutamate, which may cause anxiety, panic attacks, agitation, or inflammation. The calming nutrients and herbs, and the L-theanine in this product may help support the stressful state exhibited by high glutamate. The niacin may help use up some of the excess methyl groups, potentially allowing the health professional to use necessary Methylgenetic Nutrition supplements. From PHP/Nutritional Specialties.